M-CSF: HAEMATOPOIETIC GROWTH FACTOR OR INFLAMMATORY CYTOKINE?
Identifieur interne : 009940 ( Main/Exploration ); précédent : 009939; suivant : 009941M-CSF: HAEMATOPOIETIC GROWTH FACTOR OR INFLAMMATORY CYTOKINE?
Auteurs : P. Fixe [France] ; V. Praloran [France]Source :
- Cytokine [ 1043-4666 ] ; 1998.
English descriptors
- KwdEn :
- Academic press, Biological activities, Biological role, Blood monocytes, Bone metabolism, Breast cancer, Cell biochem, Coding sequences, Cytokine, Endothelial cells, Exon, Growth factor, Haematopoietic, Haematopoietic cells, Haematopoietic growth factor, High concentrations, Human gene, Immunol today, Isoforms, Laboratoire experimentale, Large colonies, Limoges cedex, M-CSF , CSF-1 , c-fms, biological activities, Macrophage, Macrophage colony, Macrophage factor, Membrane isoform, Metabolism, Microglial cells, Monocyte, Mrna, Osteopetrotic mouse, Other cell types, Other cytokines, Placental cells, Pollard, Praloran, Primitive progenitors, Progenitor, Receptor, Same time, Serum levels, Target cells, Tissue macrophages, Total absence, Tumoral cells, Tumour, Various isoforms.
- Teeft :
- Academic press, Biological activities, Biological role, Blood monocytes, Bone metabolism, Breast cancer, Cell biochem, Coding sequences, Cytokine, Endothelial cells, Exon, Growth factor, Haematopoietic, Haematopoietic cells, Haematopoietic growth factor, High concentrations, Human gene, Immunol today, Isoforms, Laboratoire experimentale, Large colonies, Limoges cedex, Macrophage, Macrophage colony, Macrophage factor, Membrane isoform, Metabolism, Microglial cells, Monocyte, Mrna, Osteopetrotic mouse, Other cell types, Other cytokines, Placental cells, Pollard, Praloran, Primitive progenitors, Progenitor, Receptor, Same time, Serum levels, Target cells, Tissue macrophages, Total absence, Tumoral cells, Tumour, Various isoforms.
Abstract
Abstract: Macrophage colony-stimulating factor (M-CSF), initially described as a growth factor of the mononuclear phagocytic lineage, also participates in immunological and inflammatory reactions, bone metabolism and pregnancy. All its biological activities are mediated by a tyrosine kinase receptor (M-CSF-R) that is encoded by the c-fmsprotooncogene. After a brief overview on the synthesis, structure, metabolism and signalling of M-CSF and its receptor, we present with more details the major in vitro and/or in vivo biological activities of this cytokine. A particular attention has been devoted to the results suggesting that the various M-CSD isoforms (i.e. soluble, cell-associated and matrix anchored forms) play different specific roles on target cells bearing M-CSF-R at their surface. Infectious, inflammatory and neoplastic disease in which M-CSF is involved and could participate to their physiopathology are mentioned. Finally, the role that the various isoforms of M-CSF could play in the regulation of “physiological and pathological cytokine networks” during inflammation and immune responses is discussed.
Url:
DOI: 10.1006/cyto.1997.0249
Affiliations:
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All its biological activities are mediated by a tyrosine kinase receptor (M-CSF-R) that is encoded by the c-fmsprotooncogene. After a brief overview on the synthesis, structure, metabolism and signalling of M-CSF and its receptor, we present with more details the major in vitro and/or in vivo biological activities of this cytokine. A particular attention has been devoted to the results suggesting that the various M-CSD isoforms (i.e. soluble, cell-associated and matrix anchored forms) play different specific roles on target cells bearing M-CSF-R at their surface. Infectious, inflammatory and neoplastic disease in which M-CSF is involved and could participate to their physiopathology are mentioned. Finally, the role that the various isoforms of M-CSF could play in the regulation of “physiological and pathological cytokine networks” during inflammation and immune responses is discussed.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Limousin</li><li>Nouvelle-Aquitaine</li></region><settlement><li>Limoges Cédex</li></settlement></list><tree><country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Fixe, P" sort="Fixe, P" uniqKey="Fixe P" first="P." last="Fixe">P. Fixe</name></region><name sortKey="Praloran, V" sort="Praloran, V" uniqKey="Praloran V" first="V." last="Praloran">V. Praloran</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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